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"Poison" is een glammetalnummer van de Amerikaanse zanger Alice Cooper en is wereldwijd een van zijn grootste hits. Het nummer werd geschreven door Cooper en producer Desmond Child. De single is afkomstig van Alice Cooper zijn 18e studioalbum Trash uit 1989. Op 17 juli dat jaar werd het nummer in de VS en Canada op single uitgebracht. Europa, Australië, Nieuw-Zeeland en Japan volgden op 5 september.

"Poison" is a song by American musician Alice Cooper. Written by Cooper, producer Desmond Child and guitarist John McCurry, the song was released as a single in July 1989 from Cooper's eighteenth album, Trash. It became one of Cooper's biggest hit singles in the United States, peaking at number seven on the Billboard Hot 100. The song performed even better in the UK by peaking at number two on the UK Singles Chart.

"Poison" marked a major comeback for Alice Cooper, becoming his first Top 10 hit in the US and UK for 12 and 16 years respectively, and remains one of his best known songs. It is ranked by Billboard as the "91st top song of 1989", while Ultimate Classic Rock ranked it as the "7th best Alice Cooper song", commenting "Poison sounds like a typical '80s pop-metal number at times, but Cooper’s intensity brings it to a whole other level." The song's main riff was written by guitarist John McCurry, who two years earlier had used it for the John Waite track "Encircled".