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Toxicity is het twaalfde nummer en de tweede single van het album Toxicity van de Amerikaanse metalband System of a Down.

"Toxicity" is a song by the American heavy metal band System of a Down. It was released in 2001, as the second single from their second album of the same name. The song was written by band members Daron Malakian, Shavo Odadjian, and Serj Tankian. It is known for its dynamic chorus, aggressive vocals, and prominent drum beat. The song is predominantly in triple meter, alternating between 64, 128 and 44 time. The guitar during the verse plays in 64 using a 2+2+2 phrasing while the heavy part ("somewhere between the sacred silence and sleep") makes use of a hemiola with the guitar switching to a 3+3+3+3 pattern while the drums remain in compound duple meter until the bridge. The song was ranked number 14 on VH1's 40 Greatest Metal Songs, and was called a nu metal classic by Stylus Magazine.