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Resistance is een single van de Britse rockband Muse. Het is de derde single van het album The Resistance en werd uitgebracht op 22 februari 2010. Een videoclip met beelden van een Muse-concert uit 2009 in het Palacio de Deportes de la Comunidad de Madrid werd op 14 januari al uitgegeven.

"Resistance" is a song by English rock band Muse, featured as the title track on their fifth studio album The Resistance. Written by vocalist, guitarist and pianist Matthew Bellamy, it was released as the third single from the album, following "Uprising" and "Undisclosed Desires", on 22 February 2010. The song makes several references to the novel Nineteen Eighty-Four, by George Orwell. The intro of the song is used in the trailer of the last episode of BBC show Silent Witness. In February 2010, Muse had uploaded a picture puzzle of "Resistance" artwork on their official Facebook page. The puzzle itself has a making of the "Resistance" track (which will be able to see it after solving the puzzle). The song was featured in a promo for an episode of Human Target. The song was also released as downloadable content for the music video game Guitar Hero: Warriors of Rock.